Aim: To assess systemic inflammatory biomarkers in non invasive differential diagnosis of primary central nervous system lymphoma (PCNSL) from high-grade glioma (HGG).Materials & methods: Patients with similar morphology (PCNSL or HGG) on conventional neuro-imaging were included.Systemic inflammatory indices were calculated from pretreatment complete blood counts and liver function tests and compared against histopathology as reference standard.Results: Mean Airconditioner Thermostat values of absolute lymphocyte Foot Massagers count and prognostic nutritional index were significantly different between PCNSL (n = 42) versus HGG (n = 16).
Area under receiver operating characteristics curve for absolute lymphocyte count and prognostic nutritional index in the diagnosis of PCNSL was 0.70 and 0.72 respectively suggesting fair and acceptable diagnostic accuracy.Conclusion: Systemic inflammatory biomarkers complement established clinico-radiological features and aid in the differential diagnosis of PCNSL from HGG.